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When GM dysbiosis or intestinal barrier dysfunction occurs, bacteria and endotoxins enter the liver via the biliary tract and portal vein, activating hepatic cell surface receptors and releasing inflammatory factors, thereby damaging hepatocytes and ultimately leading to liver inflammation and fibrosis

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Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate-cysteine ligase

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