127 Intriguingly, the voltage-dependent anion channel (VDAC) is a channel in the outer mitochondrial membrane
Leppink, E.W
The high toxicity of inorganic selenium (selenite and selenium dioxide) and organic selenium is related to their ability to oxidize sulfhydryl groups, leading to inactivation of sulfhydryl-containing enzymes
In these situations, the goal is usually to support mobility, maintain tissue stability, and promote consistent recovery during periods of increased physical stress
However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis
212 GessnerC.SteinchenW.BedardS.J SkinnerJ.WoodsV