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Description

127 Intriguingly, the voltage-dependent anion channel (VDAC) is a channel in the outer mitochondrial membrane

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However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis

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