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Alcohol dehydrogenase and aldehyde dehydrogenase Firstly, alcohol is taken over by the enzyme pair ADH (alcohol dehydrogenase) / ALDH (aldehyde dehydrogenase)

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By inhibiting mitochondrial complex I and suppressing TXNIP, metformin promotes GLUT1 expression and trafficking to intestinal epithelial membranes, increasing glucose excretion and uptake in the distal intestine

Redox Signal 24 , 680712 (2015)

good absorption, slightly slower than IV

Moreover, it also reduces ALA competition with other nutrients for absorption [91]