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NDGA, which exerts its inhibitory effects through interfering with the catalytic iron of LOX enzymes 70 , could reduce the levels of released 13-HODE and abolish the cytotoxicity-boosting effect of albumin
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Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial
Amador-Noguez, D
Upon receptor engagement in research models, IGF-1 LR3 activates two major downstream signaling cascades: - PI3K/Akt/mTOR pathway associated with cellular survival, protein synthesis, and anabolic signaling processes in experimental models
While CB-839 inhibited the proliferation of patient-derived glioma cell lines, it did not affect cell viability (103).In NSCLC, KEAP1 mutant NSCLC cell lines exhibit a dependence on Gln, and the GLS inhibitor CB-839 can inhibit Gln metabolism to exert anti-tumor effects (104)
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