These molecules are designed to be membrane-permeable, meaning they can cross cell membranes and access their target enzyme inside cells
Previous studies, aimed at screening anti-DMG therapeutics, often focused on investigating drug efficacy without considering drug penetration across the BBB 42,43 However, the tightness and high selectivity of the BBB, specifically in the pons, prevent the majority of drug compounds from reaching the tumor site 13 Therefore, taking into consideration drug permeation during investigations of drug efficacy, as enabled by our BBB-tumor system, helps to better predict the potential success of new compounds
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Endogenous human peptide BPC-157 Compound class: synthetic stable gastric pentadecapeptide
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