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This offers a direct reference for prostate cancer (PCa): in patients resistant to AR pathway inhibitors (e.g., abiraterone, enzalutamide), the LPA axis may serve as an analogous escape pathway. By activating non-classical AR signaling, LPA (unspecified species) drives castration-resistant PCa (CRPC)

An analysis of the mechanism reveals that the nanoparticles facilitate the oxidation of GSH into GSSG, leading to disruptions in redox balance and the antioxidant defense system and therefore accumulation of ROS and lipid peroxides

The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats

When collagen is degraded, the resulting fragments signal fibroblasts to produce new collagen

The drug causes a reddish discoloration of the urine (chromaturia, which can look like blood in the urine), and of the skin