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Day 10 cultured SCD erythroblasts were treated with 75 M hemin (#51280, Sigma) (dissolved in 0.25 M NaOH then neutralized with HCL to pH7.4), 50 M dimethyl fumarate (#242926, Sigma) (dissolved in DMSO), 0.5 mM (2S)-Tetrahydro-5-oxo-2-furancarboxylic acid (TFMB-L2HG) (#SML2563, Sigma) (dissolved in DMSO), 0.5 mM S-(5-Adenosyl)-L-methionine iodide (SAM) (#A4377, Sigma) (dissolved in water), and cultured under hypoxia (1% O 2 ) using Heracell 150i incubator equipped with an Oxygen (O 2 ) sensor and Nitrogen (N2) gas supply and analyzed on day 12 of culture
Zhao et al
Additionally, Ibrexafungerp maintains efficacy against Candida strains harboring FKS mutations, reducing the risk of cross-resistance with echinocandins (Nunnally et al., 2019)
Biomedical Research, 8, 67-74
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Rezende RALS, Rodrigues FA, Soares JDR, Silveira HRO, Pasqual M, Dias GMG
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