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The HealthRX clinical team uses the following stepwise framework for anyone starting MK-677 who also intends to supplement vitamin D: Baseline labs before starting MK-677: 25-OH vitamin D, serum calcium, phosphate, PTH, IGF-1, fasting glucose, HbA1c

Zhonghua Nan.Ke.Xue

No Blood Thinners: Avoid medications like aspirin, ibuprofen, and certain supplements (e.g., Vitamin E, fish oil) if advised by your doctor, as they can increase bruising

Ballabh P, Braun A, & Nedergaard M

Fine-tuning of NO diffusion from the endothelium to the smooth muscle cell is controlled by regulation of its Fe 2+ /Fe 3+ redox equilibrium (172)