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Taken together, the above observations suggest that B cells might play a key upstream role in MS pathogenesis, and quite unexpectedly, could be stimulated to upregulate machinery unrelated to their traditional immune functions (Lisak et al., 2012, 2017)

In the case of suspected cobalt hypersensitivity, an intradermal test dose should be administered because anaphylactic shock and death have followed parenteral administration of cyanocobalamin

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