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The effects of VIP on mucus secretion in humans are complex as an inhibitory effect of VIP on cholinergic-mediated mucus secretion in human submucosal glands has been reported [115]

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Supporting may be a dramatic decrease of glutathione levels in the rat brain after a paracetamol oral overdose (3.0 g/kg) (4) and brain tissue susceptibility to oxidative stress (high content of peroxidizable unsaturated fatty acids, high oxygen consumption per unit weight, but poorly developed antioxidative defense mechanisms) (5)

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