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FDA rulemaking follows

Risk of gastrointestinal cancer in patients with an elevated level of gamma-glutamyltransferase: A nationwide population-based study

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It is the same mechanism that makes pyridoxine effective for pregnancy nausea, chemotherapy-induced nausea, and motion sickness

In epilepsy models, pro-inflammatory cytokines downregulate this pathway via phosphatase and tensin homolog (PTEN)-mediated suppression, thereby reducing neuronal survival and synaptic efficacy