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The tumor tissue of osteosarcoma was obtained, cut into small fragment, and transplanted subcutaneously into BALB/c nude mice

The clinical treatment strategies for this disease are mainly chemical drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), glucocorticoids (GCs) and biological agents, but it is difficult for patients to accept long-term drug treatment and its side effects

K.TeradaK.GeulaC.et al

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No gross differences in morphology were observed for the duration of the experiment in the presence of all concentrations (up to 10 mM) of both reducing agents

hence, allowing Sp to effectively circumvent the ROS induced toxicity associated with the prevailing therapies