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RNAi-based drug design: considerations and future directions

A decline in ACE2 function in aged individuals, coupled with the age-associated deterioration in mitochondrial functions results in chronic metabolic disorders like diabetes or cancer, and predisposes the host for increased susceptibility to infection, vulnerability to health complications, and intensifies the risk of mortality 163

doi: 10.1016/j.chom.2018.04.008 124 SparrerK

NAFLD is associated with metabolic syndromes and the incidence of NAFLD has increased over time [4, 5]