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The dorsogluteal site has been phased out of current guidance because of its proximity to the sciatic nerve and superior gluteal artery

Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)

Pros: Generally well tolerated

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