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The classical metastatic cascade starts from a primary, epithelial, neoplastic lesion and includes: (1) epithelial mesenchymal transition (EMT) with a breach of the basement membrane barrier

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To minimize these risks, it is important to follow injection techniques and sterile practices [13]

However, in contrast to healthy rats showing sustained increases in GFR and RPF during treatment with bGH and rhIGF-1, no significant effects of these measures on GFR, RPF or filtration fraction were noted in 5/6 nephrectomized rats

J Psychiatr Res 46:132632

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