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-glutamylcysteine (GGC), a precursor to glutathione (GSH), can replenish depleted GSH levels under oxidative stress conditions, by circumventing the regulation of GSH biosynthesis and providing the limiting substrate

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610 In addition, DR-AB enhances the formation of the cell membrane NKA-1 /SLC7A11 complex and inhibits SLC7A11-dependent ferroptosis

Instead, it appears to reduce their activity through a different mechanism, possibly by converting the active form of these enzymes to an inactive state (Li et al., 2013

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A role of metallothionein-3 in radiation-induced autophagy in glioma cells