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Animal studies show that the addition of estrogen alone, or estrogen plus progesterone, can increase the size of fibroids .[ref] In the uterus, estrogen upregulates IFG-1 (insulin-like growth factor 1), EGFR, TGF-beta1

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Most GH secretagogues are poorly researched for safety and effectiveness and thus not approved for human use Currently, there are just two FDA-approved GHSs, one of which is available only as a generic medication and is used mainly for diagnosing GHD