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207 TononiG.CirelliC

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

doi: 10.1146/annurev.phyto.40.021102.150133 63 Ramirez-PradoJ

Our experience shows that simpler is often better

Did You Know: GHK-Cu shows no cytotoxic effects across wide concentration ranges in cell culture studies

As yet another alternative, an in vitro model of a round window membrane is provided and the migration of the otic agent is measured