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This is consistent with previous findings that fibrosis may accelerate -cell destruction or induce the destruction of -cell connectivity, leading to decreased insulin secretion [23, 32]

MAMs are essential for the regulation of the neuronal Ca 2+ concentration via the SERCA, the ER channels inositol 1,4,5-trisphosphate receptors, the glucose-regulated protein 75, the MCU, and the voltage-dependent anion channel (VDAC) [61]