The compound shows effectiveness across a wide dose range in animal studies (10 ng/kg to 10 mcg/kg producing comparable results), suggesting that more is not necessarily better
6b, we tested a range of concentrations from 15 to 120 g/ml of CA in the formulation, solution, or an equivalent amount of liposome in the blank formulation
E.ElyaziedM
Furthermore, kidneys from PKD1-knockout mice exhibit prominent features of ferroptosis, including the downregulation of SLC3A2, SLC7A11, and GPX4 and the upregulation of TFR1, divalent metal transporter 1, and HO-1, as well as mitochondrial abnormalities such as reduced mitochondrial cristae and ruptured mitochondrial outer membranes
11(3): p
Cancer Cell 41 , 11521169.e1157 (2023)