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To overcome this limitation, various strategies have been applied to extend the half-life of GLP-1 and to accelerate its in vivo action and potency

However, the direct use of HGF or any other protein neurotrophic factor as a therapeutic agent has two serious limitations: 1) large size and hydrophilic character, which preclude BBB permeability

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A 2022 study found sleeping for five hours or less a night at ages 50, 60, and 70 was linked to a high risk of multimorbidity, or having two or more chronic diseases like cancer or heart disease

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