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7 Over 55% of the weighting in this meta-analysis was contributed by the Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes (LOOK AHEAD) trial, which assessed whether intensive lifestyle interventions for weight loss would reduce cardiovascular morbidity and mortality in individuals with overweight or obesity and type 2 diabetes (T2DM)

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Some vials contain endotoxinsfragments of bacterial cell wallssuggesting poor manufacturing practices and a compromised supply chain