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Patients should be monitored for potential biphasic reactions following initial symptom resolution

Higher doses, such as 15 mg/d, have also been tested in short-term studies, though these did not significantly increase plasma spermidine levels owing to pre-systemic conversion into other polyamines, such as spermine (Reference Senekowitsch, Wietkamp and Grimm20)

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Poor sterile technique can lead to infections, endotoxin reactions, sepsis

Stage III NSCLCIs Surgery Still Relevant