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AMPK phosphorylates TSC2 at two sites (T1271 and S1387) that are distinct from the sites that are the AKT1 targets for phosphorylation

It achieves this by suppressing the NF-B signaling pathway ( 3.3 Chinese medicinal compound formulas Shengmai San (SMS), a traditional Chinese herbal formulation comprising three key ingredients: Panax ginseng , Ophiopogon japonicus , and Schisandra chinensis, is traditionally used for regulating cardiopulmonary function and anti-fatigue treatment

The mechanism appears to be interference with erythropoiesis

Schittenhelm, L., C.M