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It is, therefore, evident that the therapeutic effects of tamoxifen cannot be explained entirely by its blockade of ER or other estrogen receptors, especially since much of the earlier clinical data was established before the identification of ER and GPR30

PMID: 39706717

Bettermann EL, et al

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doi: 10.1016/j.jff.2017.12.028

Overall, due to the lack of clinical trials, arginase inhibitors are not currently recommended for the prevention or treatment of cardiovascular disease in clinical practice guidelines