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However, certain conditions may increase the need for carnitine, making it a conditionally essential nutrient

Carnitine metabolism and function in humans.Ann

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Prominent among these are neurochemical abnormalities and the two leading theories of neurochemical dysfunction are 1) the NMDAR hypofunction hypothesis which relates to an aberrant glutamate (Glu)/glutamine (Gln) system 1 and 2) the neuro-inflammation hypothesis which relates to altered redox balance and glutathione (GSH) levels