In dermatology, clinical trials show a 55.8% reduction in wrinkle volume at 12 weeks (71 women, Pickart et al., BioMed Res Int 2015It also increases the size of hair follicles by 30 to 50% in preclinical models
In contrast, growth hormone receptors are widely distributed throughout the body, including liver (mediating IGF-1 production), muscle (mediating protein synthesis), bone (mediating growth), adipose tissue, kidney, heart, and brain
Instead, its activity is believed to be mediated via adipocyte-specific signaling cascades, which gives the fragment a uniquely narrow pharmacological footprint for a peptide of its molecular size and makes it attractive to investigators who want clean lipolytic readouts
Oral semaglutide and alternative delivery methods Injectable semaglutide is not the only delivery option
M.ObradoviZ.MathuraV.BraunW.GarnerE
Will be interesting to see if this becomes an increasing FDA focus enforcement theme