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Gut Changes in the intestinal carnitine profile reflect the diversity and composition of the intestinal microbiota, which has potential application value in the diagnosis and monitoring of intestinal diseases

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Nat Rev Mol Cell Biol 21(8):439458

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Neuroinflammation also plays a major role, with microglial cells releasing inflammatory molecules such as TNF-, IL-6, and IL-1, along with ROS, all of which intensify neuronal damage (Liu and Wang, 2017)