No significant concerns in trials
5-Amino-1MQ vs AOD-9604: A Direct Comparison Now that we've explored each compound individually, let's get down to the brass tacks: the direct comparison of 5-Amino-1MQ vs AOD-9604
Who is a candidate, and who is not Inquire about preferred smoothness of recovery, four- to six-week daily self-injection capability and documented health history for tolerance
Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
This is why lyophilized (water-free) storage is much more stable than solution storage
Results: The 15 patients with PACNS were divided into two subgroups, with 8 patients in the first subgroup (standard therapy) and 7 patients in the second (+ rituximab)