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Continuous oxidative stress can lead to chronic inflammation, intense cytokine release and a cytokine storm as seen in SARS-CoV-2 infection in COVID-19 disease, and the viral infection enhances oxidative stress creating a fatal vicious circle between oxidative stress and cytokine storm during COVID-19 infection (Delgado-Roche and Mesta, 2020

Such transmission, first elucidated for the prion protein in a classic series of experiments (Gajdusek et al., 1966

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Thus, identifying novel therapeutics that target multiple pathways and genes associated with AD represents a promising strategy for treatment