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HIT explains that it is a clinical situation which involves accumulation of histamine in the body

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The results showed that patients with a mean baseline body weight of 106.9 kg who were treated with CagriSema (2.4/2.4 mg) achieved 22.7% weight loss after 68 weeks, compared to 11.8% of those treated with cagrilintide 2.4 mg monotherapy and 16.1% of those treated with semaglutide 2.4 mg monotherapy, and to 2.3% of those receiving only the placebo [125]

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