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For decades, its physiological relevance remained speculative, as the peptide had not yet been identified in human tissue

169(8): 16721692 Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers Bharat B Aggarwal, Subash C Gupta, and Bokyung Sung ~ PLoS One

Quantifying heterogeneity in a meta-analysis

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Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals to evaluate carcinogenic potential have not been done

Some researchers even suggest its potential role in skin rejuvenation could quietly replace more invasive cosmetic procedures