Bychkov VG, Zolotukhin VM, Khadieva ED, Kulikova SV, Petrov IM, Berdinskih SG, Lazarev SD, Morozova LF, Morozov EN
The loss-of-function mutations of several daf (DAuer Formation) genes, e.g., daf-2 (InsR/IGF-1R), age-1 (PI3K), and daf-16 (FoxO), significantly extend the lifespan of C
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Consequently, increased reactive oxygen species levels lead to decreased levels of reduced GSH and increased levels of TGF-, which has been demonstrated to inhibit the rate-limiting enzyme responsible for the de novo synthesis of GSH
Results are not permanent
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