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This vasodilator increases the availability of inflammatory mediators (TNF-, L-selectin) which, at high concentrations, can damage epithelial cells and lead to bronchial contraction (101)

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In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

These benefits match those seen with calorie restriction, which helps extend lifespan across various species [6]

ej., enfermedad renal con dilisis, ciertas medicaciones)