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Similarly, the administration of 200 micrograms per day of selenium for 8 weeks in PCOS patients had beneficial effects on their insulin metabolism parameters, triglycerides and very low-density lipoprotein-C (VLDL-C) levels (143)
Targeting specific molecular pathways of ferroptosis constitutes a promising therapeutic strategy
The downregulation of FDX1 and DLD is noteworthy, as both proteins are implicated in the cuproptosis pathway, serving as targets for copper-induced protein aggregation [11, 12]
The review described the interplay of these systems as constituting a coordinated, multi-layered defence network centred on GSH availability