The VDss is the theoretical volume that a drug needs to be uniformly distributed to produce the same plasma concentration
In the case of UreG, this creates a subunit-bridging Ni II site that is coordinated by an invariant Cys -Pro- His sequence from opposite protomers and positioned between the G2 and G3 loops in the primary structure, to form an approximately square planar Cys 2 -His 2 coordination complex (Figure 38A), 822 mutagenesis of which abolishes urease maturation
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J Endocrinol Invest 33:140146 Liaudet L, Vassalli G, Pacher P (2009) Role of peroxynitrite in the redox regulation of cell signal transduction pathways