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Astragaloside IV derivative (LS-102) alleviated myocardial ischemia reperfusion injury by inhibiting Drp1(Ser616) phosphorylation-mediated mitochondrial fission

Research examines their individual and potential synergistic effects on wound healing phases, vascular development, cellular migration, and inflammatory modulation

TFAM binds mtDNA with high affinity and promotes both replication and transcription of the mitochondrial genome, thereby supporting the synthesis of electron transport chain complexes, ribosomal RNAs, and tRNAs required for the generation of new, functional mitochondria ( Importantly, this cascade is self-limited and context-dependent

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Jelovac N., Sikiric P., Rucman R., Petek M., Perovic D., Konjevoda P., Marovic A., Seiwerth S., Grabarevic Z., Sumajstorcic J., et al

bioRxiv2024 May 1