glutathione and methyl folate Methylfolate vs Folinic Acid: Which Active Do You Need? — Seeking Health The Power of Methylated Folate:

doi: 10.1038/s41575-023-00885-x

When these conversions don't happen, then the body's blood stream is overloaded with a form of B12 it can't use or clear very quickly (hence you feel very bad afterwards)

If the application calls for water pH within a certain high/low range, then Table 1 will prove useful

They'd be stupid if they did

This is therefore given by the 1.77uM of the acid (at its solubility limit) plus the amount of the unprotonated salt that increases with increasing pH

In the body, B12 assists with detoxification because it is a critical factor of the methylation pathway that helps the body make the powerful antioxidant, glutathione