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LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

Eur J Clin Nutr

B12 oral supplements are also readily available but these take longer to work and there is no guarantee that the body will absorb them effectively due to the digestion process

Those requiring supplementationsuch as vegans, individuals with pernicious anaemia, or those with malabsorption conditionsshould follow guidance from their GP or registered dietitian to ensure appropriate dosing

Subcutaneous routes support frequent timing

Advertisement | page continues below Some studies suggest that babies born to women with low levels of vitamin B12 during pregnancy may have an increased risk of neural tube defects