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J Oleo Sci 64:133141 Nakajima S, Satoh Y, Yanashima K, Matsui T, Dairi T (2015) Ergothioneine protects Streptomyces coelicolor A3(2) from oxidative stresses

While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig

Timing: Take 1 capsule daily with water, preferably with a meal for optimal absorption

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Future research efforts should focus on developing strategies to repair and protect mitochondrial function in order to enhance the effectiveness of treatments for AP

von Petersdorff-Campen K, Schmid Daners M