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This pathway plays a critical role in tissue development and homeostasis, and its dysregulation has been widely implicated in tumorigenesis by promoting epithelial-mesenchymal transition (EMT), angiogenesis, cell proliferation, invasion, metastasis, and the maintenance of cancer stem cell-like properties 33,35,36,37,38,39

The resulting product was used for the in vitro specifically the release of entrapped Etoposide in response to the acidic tumor microenvironment, which improved drug accumulation and efficacy [15]

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