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Trends in Biotechnology, 18 (4), 160167

Many people who react to coffee assume its the caffeine

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Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks

Until then, clinicians need to consider pharmacokinetic, pharmacodynamic, metabolic, pathophysiologic and other factors that can increase the systemic exposure of statins and/or fibrates and hence heighten the risk of toxic effects on muscles, as well as data from clinical trials and recommendations of consensus panels to optimize the safety of such combination regimens