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10.1371/journal.pone.0162590 45 Lovric-BencicM.SikiricP.HanzevackiJ

Delta sleep-inducing peptide: structure-function relationships

36 In the light of the other results, we expected an increased TNF- level to be associated with beneficial response and an increased IL-1 and IL-6 levels to be associated with nonresponse

The established maximum doses represent the upper limits studied in clinical trials, beyond which risk-benefit ratios become unfavorable

That is still manageable but approaching the upper limit of what is practical

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