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The difference in E of roGFP2-iL and GRX1-roGFP2-iL suggests that N-terminal fusion of GRX1 influences the thermodynamic properties of the C147C204 disulfide

In ALS, the dysfunctional uptake of glutamate by astrocytic transporters contributes to excitotoxicity at least in a subset of ALS patients [97], however, simple inhibition of glutamate transport failed to produce an ALS-like condition in animals (see section The classical view: microglia as engines of inflammation for more details)

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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 43, 209- 216