Co-administering them can cause extreme vasodilation, leading to dangerous hypotension (low blood pressure), dizziness, and severe headaches
Agarwal A, Parekh N, Panner Selvam MK, et al
Although there is a broad agreement that naturally occurring food folate is not as bioavailable as folic acid, uncertainties still exist in relation to the extent of these differences, particularly in the context of a whole diet
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Some clinical trials have shown modest, temporary reductions in melanin index with consistent oral use, but reviews of this research describe the effect as inconsistent between studies and dependent on continued use, not a one-time or lasting change
TABLE 5 Univariable Cox proportional hazards analysis of serum GPX-3 concentration at diagnosis for each poor outcome during follow-up in patients with AAV