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In this Review, we discuss recent work that reveals the changes in white matter with ageing and neurodegenerative disease, how this relates to microglia dynamics during myelin damage and regeneration, and factors that influence the regenerative functions of microglia

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All of them represent approaches that have emerged from clinical observation, practitioner experience, and the practical reality that many people cannot tolerate the standard 2.5 mg starting dose without significant gastrointestinal distress

That makes it a hormone-like molecule akin to insulin (51 amino acids) or the popular weight-loss drugs Ozempic or Wegovy (30 to 31 amino acids)

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