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Female mice were selected and distributed into five groups
Despite treatment, hepatotoxicity occurs in 1213% of acute APAP overdoses, with 25% of cases progressing to liver failure and 0.20.5% resulting in fatalities
Multiple treatments are often required, which require little or no recovery time
For example, breast cancer cell lines had a high capacity to reach the oxidized form of VIC due to overexpression of SVCT2 genes, associated also with a higher resistance to oxidative stress
From a medical point of view, it is crucial, as these metabolites are toxic in excess