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Protein or zinc deficient diets can alter copper metabolism, so a malnourished individual might observe different outcomes than someone with adequate nutrition

For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg

Connective tissues, tendons, and ligaments may weaken as the body rapidly changes composition

While these findings remain encouraging, much of the published evidence has been generated through laboratory and animal models, and additional research is needed to further define its biological effects

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