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(Felice Crocetto)

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Many drugs look promising in cells, mice, or tissue samples but fail in later stages because: The treatment doesnt work well enough in humans It causes side effects at real doses The effect fades over time The human joint environment is much more complex than the lab So while we are hopeful, there is a long road ahead before this approach could become a real treatment

Here we report a non- canonical role of lactate dehydrogenase B (LDHB), whose main activity is the conversion of lactate to pyruvate, in protecting KRAS-mutated lung cancer from ferroptosis

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Munzel T, Sinning C, Post F, Warnholtz A, Schulz E