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Hudelist, G., Fritzer, N., Thomas, A., Niehues, C., Oppelt, P., Haas, D., & Salzer, H

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J., King, L

Once folic acid is a precursor in de novo synthesis of thymidine, MTX imbalances nucleotide pools, ultimately leading to incorrect DNA synthesis and halting cell division

Both rods and cones shed approximately 10% of their OS daily, and the discarded OS tips are ingested by the RPE 25

We believe that it is reasonable to require an enhanced disclosure to the patient who may be prescribed one of these drugs that this molecule is not as well-characterized as drugs that would normally be dispensed to patients, and the patient needs to understand that there may be a higher risk profile, and they should only be taken under the care of a physician, he said